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GLIM, Spring 1996, volume 2
Swarthmore College student publications (1874 - 2013)
1996-04-01
reformatted digital
Layers
SPthe
Activation of olfactory ee
Protein Kinases b lb aes
u y To lateral
olfactory
Granule tract
cell layer
Granule
Tee
Odorant binds to Receptor no longer itral/
binds odorants \ ed cell
Mitral f
cell layer!
the receptor
External
Blexifaxm Pen
ayer
glomerular
Gl tul
Proten Kinases Le slaver 4
are no longer Olfactory +.
active nerve layer |
Cribrifprm ee
plate;
Olfactory ann
epithelium! { f
sensory
neuron
FIGURE 3
The negative feedback loop involving receptors and pro-
tein kinases. Note that phospahtases are not included in FIGURE 4
theis loop, but are probably part of the process in a way that An outline of the basic anatomy of the olfac-
"has not yet been elucidated. (Based on Boekhoff & Breer, tory system showing the major cess types.
91992). (Efstratiadis, 1995)
Senses. In Principles of Neural Science. Kandel, Eric R., Schwartz, James H. and
Thomas M. Jessell eds. Appleton GLange. Norwalk, Connecticut.
Efstratiadis, Argivis. 1995. A new whiff of monoallelic expression. Current Biology. 5: 21—24.
Jones, David T. and Randall R. Reed. 1989. Golt: An olfactory Neuron Specific G Protein Involved in odorant Signal
Transduction. Science. 244: 790—795.
Lancet, Doron. 1994. Exclusive Receptors. Nature. 372: 321—322.
Laurent, Gilles and Hananel Davidowitz. 1994. Encoding of olfactory Information with oscillating Neural
Assemblies. Science. 265: 1872—1875.
Liu, Mingyao, Chen, Tsung—Yu, Ahamed, Basheer, Li, Jess and King—Wai Yau. 1994. Calcium—Calmodulin
Modulation of the olfactory Cyclic Nucleotide—Gated Cation Channel. Science. 266: 1348—1354.
Meisami, Esnail. Chemorepection. 1991. In Neural and Integrative Animal Phvsiologv. C. Ladd Prosser Ed. John
Wiley & Sons, Inc. New York.
Petty, Howard R. 1993. Molecular Biology of Membranes. Plenum Press. New
York.
Raming, K., Krieger, J., Strotmann J., Boekhoff, I., Kubick, S., Baumstark, C. and H. Breer. 1993. Cloning and
Expression of odorant Receptors. Nature. 361: 353—356.
Ressler, Kerry J., Sullivan Susan L. and Linda Buck. 1994. Information Coding in the olfactory System: Evidence for
a Stereotyped and Highly organized Epitope Map in the olfactory Bulb. Cell. 79: 1245— 1255.
Schleicher, Sabine, Boehoff, Ingrid, Arriza, Jeffrey, Lefkowitz, Robert J. and Heinz Breer. 1993. A Fadrenergic recep-
tor kinase—like enzyme is involved in olfactory signal termination. Proceedings of the National Academy of Science.
90: 1420—1424.
Vincent, Steven R. and Bruce T. Hope. 1992. Neurons that Say NO. Trends in Neuroscience. 15: 1O8—113.
Zufall, Frank and Stuart Firestein. 1993. Divalent Cations Block the Cyclic
Nucleotide—Gated Channel of olfactory Receptor Neurons. Journal of Neurophysiology.69: 1758—1767.
GLIM, Spring 1996, volume 2
Swarthmore College student publications (1874 - 2013)
1996-04-01
reformatted digital